Research & Clinical Trials
Accelerating discoveries from laboratory benches to patient bedsides. Our faculty investigators conduct groundbreaking basic science, translational studies, and multicenter clinical trials shaping the future of global medicine.
Active Clinical Trials Protocol Registry
Search open therapeutic clinical trials across oncology, cardiovascular surgery, neurology, and rare disease indications.
Phase II Multi-Targeted CAR-T Cell Infusion in Recurrent Glioblastoma Multiforme
Evaluating intracavitary delivery of bispecific EGFRvIII and IL13Ralpha2-targeted chimeric antigen receptor T cells in patients with histologically confirmed recurrent supratentorial glioblastoma.
Key Eligibility Criteria:
- Age 18 to 75 years
- Histologically documented recurrent WHO Grade 4 Glioblastoma
- KPS score >= 70%
- Adequate bone marrow, renal, and hepatic function
Early Intervention Transcatheter Aortic Valve Replacement in Asymptomatic Severe Aortic Stenosis (EVOLVE-AS)
A randomized trial comparing upfront transfemoral TAVR versus watchful clinical surveillance in patients with asymptomatic severe aortic stenosis and preserved left ventricular ejection fraction.
Key Eligibility Criteria:
- Age >= 65 years
- Aortic valve area <= 1.0 cm² or mean gradient >= 40 mmHg
- LVEF >= 50% with absence of symptoms on treadmill stress test
- Anatomically eligible for transfemoral TAVR
Circulating Tumor DNA-Guided Neoadjuvant Immunochemotherapy in Resectable Pancreatic Adenocarcinoma
Investigating ultra-deep cell-free DNA sequencing to tailor neoadjuvant triplet chemotherapy combined with checkpoint inhibition prior to robotic pancreaticoduodenectomy.
Key Eligibility Criteria:
- Biopsy-proven resectable or borderline resectable pancreatic adenocarcinoma
- Measurable disease by RECIST 1.1
- ECOG performance status 0 or 1
Bilateral MR-Guided Focused Ultrasound Thalamotomy for Medically Refractory Essential Tremor
Long-term registry analyzing safety, durability of tremor reduction, and quality-of-life outcomes following staged bilateral non-invasive acoustic thalamotomy.
Key Eligibility Criteria:
- Refractory essential tremor despite trials of >= 2 standard medications
- Tremor severity score indicating substantial functional limitation
Novel Endothelin Receptor Antagonist in Coronary Microvascular Dysfunction Among Women (LADY-CMD)
Assessing myocardial blood flow reserve measured by cardiac PET before and after 16 weeks of selective endothelin-A receptor blockade in symptomatic women.
Key Eligibility Criteria:
- Female patients aged 21 to 80 with persistent angina
- Coronary angiography demonstrating < 50% stenosis in epicardial vessels
- Abnormal coronary flow reserve (< 2.5) on invasive reactivity testing
Graduate Medical Education (GME)
Training 450+ medical residents and clinical fellows annually across ACGME-accredited residency programs in Internal Medicine, General Surgery, Neurosurgery, and Cardiology.
Residency Programs & Match Information →Precision Genomic Biobank
A state-of-the-art annotated clinical biospecimen repository housing over 150,000 consented tissue and liquid biopsy specimens powering biomarker discovery across California.
Core Lab Services & Investigator Access →Continuing Medical Education (CME)
Accredited by the ACCME to provide AMA PRA Category 1 Credits™ through Grand Rounds, clinical symposia, and surgical live-demonstration workshops for regional physicians.
CME Calendar & Grand Rounds Schedules →